Australian Bat Lyssavirus Infection (ABLV)

Australian bat lyssavirus infection, also known as ABLV, is a rare but potentially life-threatening viral disease caused by the Australian bat lyssavirus. This virus is closely related to the rabies virus and is found in bats in Australia.

Transmission

ABLV is primarily transmitted through the bite or scratch of an infected bat. The virus can also be spread through contact with infected bat saliva, such as when a person touches their eyes, nose, or mouth after handling an infected bat. In rare cases, ABLV may be transmitted through organ transplantation from an infected donor.

Symptoms

The symptoms of ABLV infection are similar to those of rabies and can include:

• Flu-like symptoms such as fever, headache, and fatigue
• Numbness or tingling around the bite wound
• Pain or discomfort at the site of the bite
• Agitation, aggression, or confusion
• Difficulty swallowing or excessive salivation
• Muscle weakness or paralysis
• Seizures or coma in severe cases

Incubation Period

The incubation period of ABLV, which is the time between exposure to the virus and the onset of symptoms, can range from several days to several months or even years. The average incubation period is around 2-3 months.

Diagnosis

ABLV infection is diagnosed through a combination of clinical evaluation, laboratory tests, and imaging studies. Laboratory tests may include:

• Reverse transcription polymerase chain reaction (RT-PCR) to detect the virus in saliva or tissue samples
• Serology tests to detect antibodies against the virus
• Immunofluorescence assays to detect viral antigens in tissue samples

Treatment and Prevention

There is no specific treatment for ABLV infection, but prompt medical attention after a bat bite or scratch can help prevent the development of symptoms. Post-exposure prophylaxis (PEP) may be recommended, which includes:

• Immediate washing of the wound with soap and water
• Administration of rabies immunoglobulin to provide immediate antibodies against the virus
• A series of vaccinations with a rabies vaccine to stimulate the production of antibodies against the virus

To prevent ABLV infection, it is recommended to avoid handling bats or other wild animals, and to wear protective clothing and gloves when interacting with bats. If a bat bite or scratch occurs, it is essential to seek medical attention immediately.