Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)

A Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) is a type of medication that is used to treat various mental health conditions, including depression, anxiety disorders, and some sleep disorders.

How SNRIs Work

SNRIs work by increasing the levels of two neurotransmitters in the brain: serotonin and norepinephrine. These neurotransmitters play a crucial role in regulating mood, appetite, and sleep. SNRIs block the reabsorption of these neurotransmitters into the nerve cells that release them, allowing more of them to be available for use by other nerve cells.

Conditions Treated with SNRIs

SNRIs are commonly used to treat:

• Major depressive disorder (MDD)
• Generalized anxiety disorder (GAD)
• Panic disorder
• Social anxiety disorder
• Fibromyalgia
• Chronic pain

Examples of SNRIs

Some examples of SNRIs include:

• Venlafaxine (Effexor)
• Duloxetine (Cymbalta)
• Desvenlafaxine (Pristiq)
• Levomilnacipran (Fetzima)

Side Effects of SNRIs

Common side effects of SNRIs include:

• Nausea and vomiting
• Headache
• Dizziness
• Insomnia
• Increased sweating
• Changes in appetite or weight

Contraindications and Warnings

SNRIs are not suitable for everyone, particularly those with:

• Hypersensitivity to the medication
• Uncontrolled angle-closure glaucoma
• Recent myocardial infarction or unstable heart disease
• Severe renal impairment

Pregnant or breastfeeding women should consult their doctor before taking SNRIs, as they may pose risks to the fetus or baby.

Dosage and Administration

The dosage of SNRIs varies depending on the specific medication and condition being treated. It is essential to follow the prescribed dosage and administration instructions carefully to minimize side effects and ensure effectiveness.