Restless Legs Syndrome (RLS)

Restless Legs Syndrome (RLS) is a neurological disorder characterized by an uncontrollable urge to move the legs, usually due to uncomfortable sensations such as itching, burning, or tingling. It is also known as Willis-Ekbom disease.

Symptoms

  • Uncomfortable sensations in the legs, such as itching, burning, or tingling
  • Urge to move the legs, often accompanied by restlessness or fidgeting
  • Sensations typically occur in the evening or at night, making it difficult to fall asleep
  • Relief from symptoms when moving the legs or walking
  • Worsening of symptoms when sitting or lying down for long periods
  • Pain or discomfort in the legs, which can range from mild to severe
  • Difficulty falling asleep or staying asleep due to symptoms
  • Daytime fatigue and sleepiness due to lack of quality sleep

Causes and Risk Factors

The exact cause of RLS is not fully understood, but several factors may contribute to its development:

  • Genetics: Family history of RLS increases the risk of developing the condition
  • Iron deficiency: Low iron levels in the brain may contribute to RLS symptoms
  • Kidney problems: Kidney disease or kidney failure may increase the risk of RLS
  • Nerve damage: Damage to the nerves in the legs can cause RLS symptoms
  • Diabetes: People with diabetes are more likely to develop RLS
  • Pregnancy: Hormonal changes during pregnancy may trigger RLS symptoms
  • Certain medications: Some medications, such as antidepressants and antihistamines, can worsen RLS symptoms

Treatments

Treatment for RLS typically involves a combination of lifestyle modifications and medication:

  • Lifestyle changes:
    • Regular exercise, such as walking or stretching, to reduce symptoms
    • Establishing a regular sleep schedule and creating a relaxing bedtime routine
    • Avoiding caffeine, nicotine, and alcohol, which can worsen symptoms
    • Massaging the legs or using heat or cold packs to relieve discomfort
  • Medications:
    • Dopaminergic agents: Medications such as ropinirole and pramipexole, which mimic the effects of dopamine in the brain
    • Opioids: In some cases, opioids may be prescribed to relieve pain and discomfort
    • Muscle relaxants: Medications such as clonazepam or gabapentin, which can help reduce muscle tension and promote relaxation
    • Iron supplements: If iron deficiency is suspected, iron supplements may be prescribed to alleviate symptoms

Alternative Therapies

Some people with RLS may find relief from alternative therapies, including:

  • Acupuncture: A traditional Chinese medicine technique that involves inserting small needles into specific points on the body
  • Massage therapy: Massaging the legs or using other massage techniques to promote relaxation and reduce muscle tension
  • Yoga and tai chi: Practicing gentle stretches and movements to improve flexibility and balance
  • Aromatherapy: Using essential oils such as lavender or peppermint to promote relaxation and reduce stress

Complications

If left untreated, RLS can lead to complications such as:

  • Sleep deprivation: Chronic lack of sleep can affect mood, cognitive function, and overall health
  • Anxiety and depression: RLS symptoms can contribute to the development of anxiety and depression
  • Reduced quality of life: RLS can interfere with daily activities, social relationships, and work or school performance

Frequently Asked Questions (FAQs)

What is Restless Legs Syndrome (RLS)?
A neurological disorder characterized by an uncontrollable urge to move the legs.

What are the symptoms of RLS?
Uncomfortable sensations in the legs, such as tingling, burning, or itching, often accompanied by a strong urge to move.

When do RLS symptoms typically occur?
Usually at night, especially when resting or relaxing.

Can RLS affect other parts of the body?
While primarily affecting the legs, some people may experience similar sensations in their arms.

Is RLS a rare condition?
No, it is relatively common, affecting approximately 7-10% of the general population.

What are potential triggers for RLS symptoms?
May include iron deficiency, kidney problems, diabetes, and certain medications.

Can lifestyle changes help manage RLS symptoms?
Possibly, regular exercise, stress reduction, and avoiding caffeine and alcohol may help alleviate symptoms.

Are there any treatments available for RLS?
Yes, including medications such as dopamine agonists, opioids, and muscle relaxants.

Can RLS be associated with other medical conditions?
May be linked to conditions like peripheral neuropathy, Parkinson's disease, and sleep disorders.

Is RLS a progressive condition?
Symptoms can worsen over time in some individuals, but the rate of progression varies widely.

Article last updated on: 18th October 2025.
If you have any feedback, please get in touch.

See more

 Conditions  Symptoms  Procedures

Diagnosis Pad
Medical AI Assistant with Differentials, Guidance, Transcriptions, Notes, Medical Encyclopedia and Explainable AI.
Download from App Store Download from Google Play
Available for iOS, macOS and Android.

Medical Disclaimer

The information provided is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this site. We we do not guarantee, and assume no legal liability or responsibility for the accuracy, currency, or completeness of the information provided.