Nongonococcal Urethritis (NGU)

Nongonococcal urethritis (NGU) is an infection of the urethra, which is the tube that carries urine from the bladder to the outside of the body. NGU is caused by bacteria other than Neisseria gonorrhoeae, which is the bacterium that causes gonorrhea.

Causes and Risk Factors

NGU is typically caused by sexually transmitted infections (STIs), such as:

Risk factors for NGU include:

  • Unprotected sex with multiple partners
  • Previous history of STIs
  • Young age (15-24 years old)
  • Male sex

Symptoms

Symptoms of NGU may include:

  • Dysuria (painful urination)
  • Urethral discharge or bleeding
  • Frequent or urgent need to urinate
  • Pain or discomfort in the penis, testicles, or groin area
  • Itching or burning sensation in the urethra

Diagnosis

NGU is typically diagnosed through a combination of:

  • Physical examination
  • Medical history
  • Urine tests, such as:
    • Urinalysis
    • Urine culture
    • Nucleic acid amplification tests (NAATs)
  • Swab tests to collect discharge or cells from the urethra

Treatment

Treatment for NGU typically involves antibiotics, such as:

  • Azithromycin (Zithromax)
  • Doxycycline (Vibramycin)
  • Levofloxacin (Levaquin)

Treatment may also involve:

  • Antiviral medications for HSV or other viral infections
  • Pain relief medications, such as acetaminophen or ibuprofen

Complications and Prevention

If left untreated, NGU can lead to complications, such as:

To prevent NGU, it is recommended to:

  • Practice safe sex with condoms or other barrier methods
  • Get regular STI screenings
  • Avoid sharing sex toys or personal items
  • Wash hands and genitals regularly

Frequently Asked Questions (FAQs)

What is Nongonococcal urethritis?
Inflammation of the urethra not caused by gonorrhea, often due to other bacterial infections.

What are common causes of Nongonococcal urethritis?
Typically caused by Chlamydia trachomatis or Mycoplasma genitalium bacteria.

What are symptoms of Nongonococcal urethritis?
May include discharge, burning during urination, and itching or irritation in the urethra.

How is Nongonococcal urethritis diagnosed?
Usually through urine tests, swab samples, or other laboratory tests to identify the causative bacteria.

Can Nongonococcal urethritis be treated with antibiotics?
Yes, often treated with azithromycin or doxycycline antibiotics, depending on the cause.

Is Nongonococcal urethritis contagious?
Yes, can be spread through sexual contact with an infected person.

Can Nongonococcal urethritis lead to complications if left untreated?
Possibly, may lead to epididymitis, prostatitis, or other complications in some cases.

How can Nongonococcal urethritis be prevented?
Using condoms during sex and practicing safe sex may reduce the risk of transmission.

Can women also get Nongonococcal urethritis?
Yes, although it is more common in men, women can also contract the infection.

Is there a cure for Nongonococcal urethritis?
Typically, with proper antibiotic treatment, most cases can be effectively treated and cured.

Article last updated on: 18th October 2025.
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