Melanoma Skin Cancer

Melanoma is a type of skin cancer that originates from melanocytes, the cells responsible for producing pigment in the skin. It is considered one of the most aggressive and deadly forms of skin cancer.

Causes and Risk Factors

• Exposure to ultraviolet (UV) radiation from the sun or tanning beds increases the risk of developing melanoma.
• Genetic mutations, such as those found in families with a history of melanoma, can also contribute to the development of the disease.
• Weakened immune system, fair skin, and a history of blistering sunburns are additional risk factors.

Symptoms

The most common symptom of melanoma is a new or changing mole. The ABCDE rule can help identify suspicious moles:

• A: Asymmetry - the mole is not symmetrical.
• B: Border - the edges are irregular, ragged, or blurred.
• C: Color - the color is uneven, with shades of brown, black, or tan.
• D: Diameter - the mole is larger than 6mm in diameter.
• E: Evolving - the mole is changing in size, shape, or color over time.

Types of Melanoma

• Superficial spreading melanoma: the most common type, often appearing as a flat, irregularly-shaped mole.
• Nodular melanoma: a more aggressive type, typically presenting as a raised, dome-shaped nodule.
• Lentigo maligna melanoma: a rare type, usually occurring on sun-exposed areas of the skin in older adults.
• Acral lentiginous melanoma: a rare and aggressive type, often appearing on the palms, soles, or under the nails.

Diagnosis

Diagnosis typically involves a combination of:

• Visual examination of the skin by a dermatologist.
• Biological sample (biopsy) of the suspicious mole or lesion.
• Pathological examination of the biopsy sample to confirm the presence of cancer cells.

Treatment Options

Treatment for melanoma depends on the stage and location of the cancer:

• Surgical excision: removal of the tumor and surrounding tissue.
• Chemotherapy: using medications to kill cancer cells.
• Radiation therapy: using high-energy rays to destroy cancer cells.
• Immunotherapy: stimulating the immune system to attack cancer cells.
• Targeted therapy: using medications that target specific genetic mutations in melanoma cells.

Stages of Melanoma

The stages of melanoma are classified based on the thickness and spread of the tumor:

• Stage 0: melanoma in situ, where cancer cells are only found in the outer layer of skin.
• Stage I: early-stage melanoma, with a tumor less than 1mm thick.
• Stage II: intermediate-stage melanoma, with a tumor between 1-4mm thick.
• Stage III: advanced-stage melanoma, with a tumor greater than 4mm thick or spread to nearby lymph nodes.
• Stage IV: metastatic melanoma, where cancer has spread to distant organs or lymph nodes.

Prevention and Screening

To reduce the risk of developing melanoma:

• Avoid exposure to UV radiation from the sun or tanning beds.
• Use protective clothing, such as hats and long-sleeved shirts, when spending time outdoors.
• Apply sunscreen with a Sun Protection Factor (SPF) of at least 30 regularly.
• Conduct regular skin self-exams to monitor for new or changing moles.
• Schedule annual skin exams with a dermatologist, especially if you have a family history of melanoma.