Medication Overuse Headaches

Medication overuse headaches (MOH) are a type of headache disorder that occurs when an individual takes too many pain-relieving medications, leading to an increase in frequency and severity of headaches.

Causes and Risk Factors

MOH is often caused by the frequent or excessive use of over-the-counter (OTC) or prescription pain medications, such as:

  • Triptans
  • Ergots
  • Opoids
  • Combination analgesics (e.g., acetaminophen and codeine)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or naproxen

Individuals who are at risk of developing MOH include those who:

Symptoms

The symptoms of MOH may vary from person to person but often include:

  • Frequent headaches (more than 15 days per month)
  • Headaches that worsen over time
  • Headaches that are more severe or longer-lasting than usual
  • Sensitivity to light, sound, or smells
  • Nausea and vomiting

Diagnosis

MOH is typically diagnosed based on a combination of:

  • Medical history
  • Physical examination
  • Headache diary or calendar to track headache frequency and severity
  • Imaging studies (e.g., MRI or CT scan) to rule out other underlying conditions

Treatment and Management

Treatment for MOH typically involves:

  • Withdrawal from the overused medication(s)
  • Pain management with alternative medications, such as:
    • Corticosteroids to reduce inflammation
    • Anti-nausea medications
    • Preventive medications (e.g., topiramate or propranolol) to reduce headache frequency
  • Lifestyle modifications, such as:

Prevention

To prevent MOH, individuals can take the following steps:

  • Use pain medications only as directed by a healthcare provider
  • Keep a headache diary to track medication use and headache frequency
  • Avoid overusing or combining multiple pain medications
  • Seek medical attention if headaches worsen or become more frequent

Frequently Asked Questions (FAQs)

What are medication overuse headaches?
Headaches that occur due to frequent or excessive use of headache medications.

What causes medication overuse headaches?
Overuse of pain-relieving medications, possibly leading to rebound effect.

Which medications can lead to medication overuse headaches?
Triptans, ergots, opioids, and combination analgesics, among others, may contribute.

How often do headaches need to occur to be considered medication overuse headaches?
Typically, 15 or more days per month for at least 3 months.

Are medication overuse headaches the same as rebound headaches?
Often used interchangeably, but some sources distinguish between the two terms.

Can anyone develop medication overuse headaches?
Possibly, especially those with pre-existing headache disorders.

How are medication overuse headaches diagnosed?
Through medical history, physical examination, and possibly, withdrawal from offending medications.

What is the treatment for medication overuse headaches?
Gradual withdrawal from overused medications, possibly under medical supervision.

Can lifestyle changes help manage medication overuse headaches?
Possibly, through stress reduction, regular sleep patterns, and healthy habits.

Is it possible to prevent medication overuse headaches?
Likely, by using headache medications judiciously and as directed.

Article last updated on: 18th October 2025.
If you have any feedback, please get in touch.

See more

 Conditions  Symptoms  Procedures

Diagnosis Pad
Medical AI Assistant with Differentials, Guidance, Transcriptions, Notes, Medical Encyclopedia and Explainable AI.
Download from App Store Download from Google Play
Available for iOS, macOS and Android.

Medical Disclaimer

The information provided is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this site. We we do not guarantee, and assume no legal liability or responsibility for the accuracy, currency, or completeness of the information provided.