Insect Bite Hypersensitivity Reaction

An insect bite hypersensitivity reaction occurs when the body's immune system overreacts to the saliva or venom from an insect bite, leading to an allergic reaction. This reaction can range from mild to severe and can cause a variety of symptoms.

Causes

Insect bites that can trigger a hypersensitivity reaction include:

  • Mosquitoes
  • Flies
  • Fleas
  • Ticks
  • Bed bugs
  • Ants
  • Bees
  • Wasps
  • Hornets
  • Yellow jackets

Symptoms

Symptoms of an insect bite hypersensitivity reaction can include:

  • Redness and swelling at the bite site
  • Itching or burning sensation
  • Hives or welts
  • Blisters or rash
  • Swollen lymph nodes
  • Fever
  • Headache
  • Fatigue

Severity Levels

Insect bite hypersensitivity reactions can be classified into three severity levels:

  • Mild: Localized reaction with redness, swelling, and itching at the bite site.
  • Moderate: Widespread reaction with hives, blisters, or rash, and possibly swollen lymph nodes and fever.
  • Severe (Anaphylaxis): Life-threatening reaction with symptoms such as difficulty breathing, rapid heartbeat, dizziness, and a drop in blood pressure.

Treatment

Treatment for an insect bite hypersensitivity reaction depends on the severity of the reaction:

  • Mild reactions: Topical creams or ointments to reduce itching and inflammation, such as hydrocortisone cream or calamine lotion.
  • Moderate reactions: Oral antihistamines or corticosteroids to reduce allergic symptoms.
  • Severe reactions (Anaphylaxis): Emergency medical treatment with epinephrine injections, such as an EpiPen, and hospitalization for close monitoring.

Prevention

To prevent insect bite hypersensitivity reactions:

  • Avoid areas where insects are common
  • Wear protective clothing, such as long sleeves and pants
  • Use insect repellents, such as DEET or picaridin
  • Avoid sweet-smelling perfumes or colognes that may attract insects

Article last updated on: 15th June 2025.
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