Hormone Replacement Therapy (HRT)

Hormone replacement therapy (HRT) is a medical treatment that involves taking hormones to replace the body's natural hormones when they are low or imbalanced. The goal of HRT is to alleviate symptoms and prevent health problems caused by hormone deficiencies.

Types of HRT

  • Estrogen replacement therapy (ERT): This type of HRT involves taking estrogen alone, typically for women who have had a hysterectomy.
  • Combined estrogen and progesterone therapy (EPT): This type of HRT involves taking both estrogen and progesterone, typically for women who still have their uterus.
  • Testosterone replacement therapy (TRT): This type of HRT involves taking testosterone, typically for men with low testosterone levels.

Indications for HRT

  • Menopause symptoms: HRT is often used to alleviate symptoms such as hot flashes, night sweats, and vaginal dryness in women going through menopause.
  • Low testosterone: TRT is used to treat low testosterone levels in men, which can cause symptoms such as low libido, fatigue, and osteoporosis.
  • Hypogonadism: HRT is used to treat hypogonadism, a condition where the sex glands (ovaries or testes) do not produce enough hormones.
  • Gender dysphoria: HRT may be used as part of the treatment for gender dysphoria, a condition where a person's gender identity does not match their biological sex.

Benefits of HRT

  • Relief from menopause symptoms: HRT can help alleviate symptoms such as hot flashes, night sweats, and vaginal dryness in women going through menopause.
  • Improved bone density: HRT can help improve bone density, reducing the risk of osteoporosis and fractures.
  • Improved libido: TRT can help improve libido and sexual function in men with low testosterone levels.
  • Improved overall health: HRT may also have benefits for overall health, such as reducing the risk of heart disease and improving cognitive function.

Risks and Side Effects of HRT

  • Blood clots: HRT may increase the risk of blood clots, which can lead to stroke or heart attack.
  • Breast cancer: Some studies have suggested that HRT may increase the risk of breast cancer, although the evidence is not conclusive.
  • Endometrial cancer: EPT may increase the risk of endometrial cancer in women who still have their uterus.
  • Weight gain: HRT can cause weight gain, particularly in women taking estrogen-only therapy.

Administration of HRT

  • Oral tablets or capsules: HRT can be taken orally in the form of tablets or capsules.
  • Patches: HRT can also be administered through patches, which are applied to the skin and release hormones slowly over time.
  • Gels or creams: Some forms of HRT involve applying gels or creams to the skin, which are absorbed into the bloodstream.
  • Injections: TRT is often administered through injections, typically given every few weeks.

Monitoring and Follow-up

Regular monitoring and follow-up appointments with a healthcare provider are essential for women or men undergoing HRT. This includes regular blood tests to check hormone levels, as well as monitoring for any side effects or health problems.

Frequently Asked Questions (FAQs)

What is Hormone Replacement Therapy (HRT)?
HRT is a medical treatment that involves taking hormones to replace those that the body is no longer producing.

Why is HRT used?
HRT is typically used to treat symptoms of menopause, such as hot flashes and osteoporosis, and to alleviate symptoms of hormone deficiency.

What types of hormones are used in HRT?
The most common hormones used in HRT are estrogen and progesterone, sometimes combined with testosterone.

How is HRT administered?
HRT can be administered through pills, patches, creams, gels, or injections.

Are there risks associated with HRT?
Yes, potential risks include blood clots, stroke, and certain types of cancer, although the likelihood may depend on various factors.

Can anyone undergo HRT?
Generally, HRT is recommended for women with severe menopausal symptoms, but it may not be suitable for everyone, particularly those with certain medical conditions.

How long can HRT be taken?
The duration of HRT varies depending on individual needs and health status, typically ranging from a few months to several years.

Are there alternative treatments to HRT?
Yes, alternatives may include lifestyle changes, non-hormonal medications, and other therapies, which may be considered based on individual circumstances.

Does HRT affect fertility?
HRT is not intended to enhance fertility, and its effects on fertility can vary depending on the type and duration of treatment.

Is HRT covered by insurance?
Coverage for HRT may vary depending on the specific insurance plan and policy terms.

Article last updated on: 18th October 2025.
If you have any feedback, please get in touch.

See more

 Conditions  Symptoms  Procedures

Diagnosis Pad
Medical AI Assistant with Differentials, Guidance, Transcriptions, Notes, Medical Encyclopedia and Explainable AI.
Download from App Store Download from Google Play
Available for iOS, macOS and Android.

Medical Disclaimer

The information provided is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this site. We we do not guarantee, and assume no legal liability or responsibility for the accuracy, currency, or completeness of the information provided.