Depression (Melancholic)

What is Melancholic Depression?

Melancholic depression is a subtype of major depressive disorder, characterized by a loss of interest or pleasure in activities that were once enjoyed. It is also known as endogenous depression, and is often described as a more severe form of depression.

Symptoms of Melancholic Depression

The symptoms of melancholic depression can vary from person to person, but common symptoms include:

  • Loss of interest or pleasure in activities that were once enjoyed
  • Depressed mood, such as feeling sad, empty, or hopeless
  • Changes in appetite or weight, such as a decrease in appetite or significant weight loss
  • Changes in sleep patterns, such as insomnia or hypersomnia
  • Fatigue or low energy
  • Feelings of worthlessness or guilt
  • Difficulty concentrating or making decisions
  • Recurrent thoughts of death or suicidal ideation
  • Psychomotor agitation or retardation, such as restlessness or slowed movements

Treatments for Melancholic Depression

Treatment for melancholic depression usually involves a combination of medication and psychotherapy. The goal of treatment is to help manage symptoms, improve mood, and increase interest in activities.

Medications

  • Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine or sertraline
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs), such as venlafaxine or duloxetine
  • Tricyclic antidepressants (TCAs), such as imipramine or amitriptyline
  • Monoamine oxidase inhibitors (MAOIs), such as phenelzine or tranylcypromine
  • Atypical antidepressants, such as bupropion or mirtazapine

Psychotherapies

  • Cognitive-behavioral therapy (CBT), which helps individuals identify and change negative thought patterns and behaviors
  • Interpersonal therapy (IPT), which focuses on improving relationships and communication skills
  • Psychodynamic therapy, which explores the underlying causes of depression and helps individuals develop more adaptive coping mechanisms
  • Electroconvulsive therapy (ECT), which may be used in severe cases of melancholic depression that have not responded to other treatments

Lifestyle Changes

In addition to medication and psychotherapy, making lifestyle changes can help manage symptoms of melancholic depression. These include:

  • Getting regular exercise, such as walking or jogging
  • Eating a healthy diet, including plenty of fruits, vegetables, and whole grains
  • Getting enough sleep, aiming for 7-8 hours per night
  • Practicing stress-reducing techniques, such as meditation or yoga
  • Staying connected with friends and family, and building a support network

Prognosis

The prognosis for melancholic depression varies depending on the individual and the severity of symptoms. With treatment, many people are able to manage their symptoms and improve their quality of life. However, it is common for individuals with melancholic depression to experience recurring episodes of depression throughout their lives.

Article last updated on: 11th April 2025.
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