Depot Medroxyprogesterone Acetate (DMPA) Injection

Introduction

Depot medroxyprogesterone acetate (DMPA), also known as the depo shot, is a type of contraceptive injection that contains the hormone progestin. It is used to prevent pregnancy and is administered via intramuscular injection every 12 weeks (or 3 months).

How it Works

DMPA works by preventing ovulation, which means that eggs are not released from the ovaries. It also thickens cervical mucus, making it difficult for sperm to reach an egg if one is released. Additionally, DMPA causes changes in the uterine lining, making it less likely for a fertilized egg to implant.

Administration

The DMPA injection is typically administered by a healthcare provider in the upper arm or buttock. The first injection can be given at any time during the menstrual cycle, as long as pregnancy can be ruled out. Subsequent injections are usually given every 12 weeks, with a 4-week grace period allowed for each injection.

Benefits

The benefits of DMPA include:

Risks and Side Effects

Common side effects of DMPA include:

Contraindications

DMPA is not recommended for women who:

  • Are pregnant or think they may be pregnant
  • Have a history of breast cancer
  • Have liver disease or liver tumors
  • Have a history of blood clots or stroke
  • Are taking certain medications, such as anticonvulsants or barbiturates

Return to Fertility

After stopping DMPA injections, it may take several months for fertility to return. On average, it can take around 9-12 months for ovulation to resume and for women to become pregnant after stopping the injections.

Monitoring and Follow-up

Women using DMPA should have regular check-ups with their healthcare provider every 3-6 months to monitor their health and address any concerns or side effects. Blood pressure and weight should be monitored regularly, and a physical exam should be performed annually.

Frequently Asked Questions (FAQs)

What is Depot medroxyprogesterone acetate injection used for?
Birth control and to treat endometriosis.

How often is the injection given?
Typically every 12 weeks.

What are common side effects of the injection?
Weight gain, breast tenderness, and mood changes.

Can the injection cause bone loss?
Possibly, particularly with long-term use.

Is the injection suitable for all women?
Not for women with certain medical conditions or taking certain medications.

Can the injection be used by breastfeeding women?
Generally not recommended in the first six weeks postpartum.

Are there any potential risks to fertility after stopping the injection?
Fertility may be delayed for some time after stopping.

Is a prescription required for the injection?
Yes, it is available by prescription only.

Can the injection protect against sexually transmitted infections?
No, it does not provide protection against STIs.

Article last updated on: 18th October 2025.
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