Chordoma
Chordoma is a rare type of cancer that occurs in the bones of the spine and skull. It is a slow-growing tumor that arises from the remnants of the notochord, a precursor to the spinal cord.
Causes and Risk Factors
The exact cause of chordoma is unknown, but it is thought to be related to genetic mutations. Risk factors include:
- Age: Chordoma typically affects adults between the ages of 40 and 70.
- Sex: Men are more likely to develop chordoma than women.
- Family history: Some cases of chordoma may be related to a family history of the disease.
Symptoms
The symptoms of chordoma can vary depending on the location and size of the tumor. Common symptoms include:
- Pain or numbness in the back, neck, or head
- Weakness or paralysis of the arms or legs
- Difficulty with bladder or bowel function
- Dizziness or loss of balance
- Double vision or other vision problems
Diagnosis
Chordoma is typically diagnosed using a combination of imaging tests and biopsy. Imaging tests may include:
- X-rays
- Computed tomography (CT) scans
- Magnetic resonance imaging (MRI) scans
A biopsy involves removing a sample of tissue from the tumor and examining it under a microscope for cancer cells.
Treatment
Treatment for chordoma usually involves surgery to remove the tumor, followed by radiation therapy to kill any remaining cancer cells. In some cases, chemotherapy may also be used.
- Surgery: The goal of surgery is to remove as much of the tumor as possible while preserving surrounding tissues and nerves.
- Radiation therapy: Radiation therapy uses high-energy beams to kill cancer cells. It may be used after surgery to reduce the risk of recurrence.
- Chemotherapy: Chemotherapy uses drugs to kill cancer cells. It may be used in combination with radiation therapy or as a standalone treatment.
Prognosis
The prognosis for chordoma varies depending on the location and size of the tumor, as well as the effectiveness of treatment. In general, the 5-year survival rate for people with chordoma is around 50-60%. However, with prompt and effective treatment, some people may be able to achieve long-term remission or even cure.
Frequently Asked Questions (FAQs)
What is Chordoma?
A rare type of bone cancer that typically occurs in the spine and base of the skull.
What are the common locations of Chordoma tumors?
Base of the skull, spine, and sacrum.
Is Chordoma a fast-growing cancer?
Typically slow-growing, but can be locally aggressive.
What are the symptoms of Chordoma?
Pain, numbness, tingling, and weakness, depending on tumor location.
How is Chordoma diagnosed?
Imaging tests such as MRI or CT scans, and biopsy.
What is the treatment for Chordoma?
Surgery, radiation therapy, and sometimes chemotherapy.
Is Chordoma hereditary?
Most cases are sporadic, but some may be associated with genetic syndromes.
Can Chordoma be cured?
Possibly, with early detection and effective treatment, but recurrence is common.
What is the prognosis for Chordoma patients?
Varies depending on tumor location, size, and response to treatment.
Are there any ongoing research or clinical trials for Chordoma?
Yes, researchers are exploring new treatments, including targeted therapies and immunotherapies.
Article last updated on: 18th October 2025.
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