17-Hydroxyprogesterone (17-OHP) Test
The 17-hydroxyprogesterone (17-OHP) test is a blood test used to measure the level of 17-OHP in the blood. 17-OHP is a hormone produced by the adrenal glands, which are located on top of the kidneys.
What is 17-Hydroxyprogesterone?
17-OHP is a steroid hormone that is produced as an intermediate step in the production of cortisol, a stress hormone produced by the adrenal glands. It is also involved in the production of androgens, such as testosterone and dihydrotestosterone (DHT).
Purpose of the Test
The 17-OHP test is used to diagnose and monitor several conditions, including:
- Congenital adrenal hyperplasia (CAH): a genetic disorder that affects the production of cortisol and aldosterone, leading to an overproduction of androgens.
- Cushing's syndrome: a condition caused by excess levels of cortisol in the body.
- Adrenal insufficiency: a condition where the adrenal glands do not produce enough hormones.
- Precocious puberty: a condition where children enter puberty too early.
How is the Test Performed?
The 17-OHP test is typically performed by taking a blood sample from a vein in the arm. The blood sample is then sent to a laboratory for analysis.
Interpretation of Results
The results of the 17-OHP test are usually measured in nanograms per milliliter (ng/mL) or nanomoles per liter (nmol/L). The normal range for 17-OHP levels varies depending on the laboratory and the individual's age, sex, and medical condition.
Abnormal Results
Abnormal results may indicate:
- Elevated 17-OHP levels: may indicate CAH, Cushing's syndrome, or adrenal insufficiency.
- Decreased 17-OHP levels: may indicate adrenal insufficiency or hypopituitarism (a condition where the pituitary gland does not produce enough hormones).
Risks and Limitations
The 17-OHP test is generally a safe and accurate test. However, as with any blood test, there may be some risks and limitations, including:
- Bleeding or bruising at the needle site.
- Infection at the needle site.
- False-positive or false-negative results due to laboratory error or interference from other medications or medical conditions.
Article last updated on: 15th June 2025.
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